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3 days ago · The Power Reactor Information System (PRIS), developed and maintained by the IAEA for over five decades, is a comprehensive database focusing on nuclear power plants worldwide Mar 1, 2024 · Future work could use case-control methodology to understand risk factors and pathogenesis of PRIS  Importantly, our study quantified the incidence for use of the TIVA technique and the extremely rare incidence of PRIS in a nationally representative sample of paediatric anaesthesia care in Japan Background PRIS = propofol infusion syndrome Refractory bradycardia and cardiovascular collapse Poorly understood mechanism Risk factors High doses of (> 4mg kg hr or 67 mcg kg min) Long duration (> 48 hrs) Younger age (PRIS first recognized in pediatric population) Critical illness Malnutrition Liver disease Carnitine deficiency Mitochondrial    Apr 30, 2024 · Propofol-related infusion syndrome (PRIS) is a rare but severe condition associated with the administration of propofol, an anesthetic commonly used for sedation in medical procedures  First identified in the 1990s, PRIS can be fatal if not recognized and treated promptly Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol Propofol-related Infusion Syndrome (PRIS) is a life-threatening condition characterised by acute refractory bradycardia progressing to asystole and one or more of:Feb 5, 2024 · Aside from propofol dose, other risk factors for PRIS include critical illness, use of vasopressors and steroids, starvation or malnutrition, and subclinical mitochondrial disease The term PRIS—propofol infusion syndrome—was originally coined by Bray in 1998 to describe the adverse effects associated with the use of propofol in the paediatric population The term “propofol infusion syndrome” (PRIS) first appeared in pediatric literature and was proposed by Bray who had reviewed 18 pediatric cases [5]  The clinical spectrum of PRIS consists of bradycardia, cardiovascular collapse, HAGMA, rhabdomyolysis, hepatomegaly, and lipemia [5] Mechanism of PRIS High doses of propofol (greater than 3mg kg h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism

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